Abstract: 【Objective】The Budongquan area is characterized by rugged topography and strong interference from snow, ice, and bright surface materials, resulting in considerable ambiguity in alteration anomalies derived from a single sensor. This study aims to identify hydrothermal alteration anomalies and assess mineral prospectivity by integrating multi-source remote sensing data with geological and field evidence.【Methods】Landsat 8 OLI and Sentinel-2 MSI images were processed using band ratios, selective principal component analysis, and cross-sensor class matching to extract iron-oxide–hydroxyl alteration anomalies and suspected high-reflectance anomalies. Fault proximity, favorable stratigraphic units, intrusive contacts, known mineral occurrences, and field observations were then integrated to delineate mineral prospectivity zones.【Results】The combined area of moderately and highly reliable iron-oxide–hydroxyl anomalies was 817.44 km², accounting for 94.93% of the total reliability-classified anomaly area. Moderate-to-strong suspected high-reflectance anomalies covered 261.43 km². A continuous E–W to WNW–ESE-trending iron-oxide–hydroxyl anomaly belt occurs in the southern part of the study area, whereas the northeastern high-reflectance anomalies show close spatial associations with dense faults, favorable stratigraphic units, and known mineral occurrences. Field observations identified contact fracture zones, quartz veins, epidote and quartz veins, quartz lenses, and granite-porphyry dikes, providing geological support for the interpretation of the major anomalies. One Class I and three Class II mineral prospectivity zones were delineated.【Conclusion】Cross-sensor matching combined with geological and field constraints can reduce false-positive interpretations associated with single-source anomalies and provide an effective basis for regional mineral targeting in high-altitude, sparsely vegetated areas. The mineralization potential of the southern predicted zones requires further evaluation through targeted sampling and mineralogical analyses.