Abstract: [Objective] The Xihuashan area is situated in the eastern segment of the North Qilian Orogenic Belt and represents one of the regions in Ningxia with the most favorable conditions for gold-polymetallic mineralization and the most concentrated mineralization occurrences. While several small-scale gold-polymetallic deposits, mineral occurrences/mineralized spots, and geophysical/geochemical anomalies have been discovered in this area, the overall level of exploration remains low, and no major prospecting breakthrough has been achieved. [Methods] Based on a systematic review of previous exploration results in the area, this study clarified the ore-controlling factors for gold-polymetallic deposits, established a comprehensive prospecting model integrating geology, geophysics, geochemistry, and remote sensing (multi-source information), and subsequently delineated prospecting targets. [Results] The research indicates that gold-polymetallic mineralization in the Xihuashan area is primarily controlled by structures and stratigraphy. Structurally, it exhibits a three-level ore-controlling pattern: first-order NW-trending faults serve as ore-conducting structures; second-order NNW-trending faults act as ore-distributing structures; and third-order NW-NWW-trending faults function as ore-hosting structures. Stratigraphically, the Tianhushan Formation is favorable for gold mineralization, whereas the Bojizhang Formation is favorable for copper mineralization. The results of 1: 5, 000 induced polarization (IP) surveys in the Liugou area show that medium-high resistivity coupled with high chargeability anomalies are typically caused by mineralization. In 1: 50, 000 stream sediment surveys, the Au-Cu-Ag-As-Mo and Pb-Au-As-Ag elemental association anomalies exhibit high intensity and wide distribution. Furthermore, hyperspectral remote sensing data from WorldView-3, processed via Principal Component Analysis (PCA), effectively extracted aluminum-hydroxyl anomalies, carbonatization anomalies, and iron-staining anomalies, whose spatial distribution shows good correspondence with some known gold-polymetallic deposits. [Conclusion] By integrating multi-source information from geology, geophysics, geochemistry, and hyperspectral remote sensing, a total of five prospecting targets were delineated, including three Category I targets and two Category II targets, reflecting variations in prospecting potential across different areas. Among them, the Machang, Bojizhang-Laoyesi, and Liugou areas are classified as Category I targets, characterized by superior metallogenic geological conditions and high prospecting potential. Verification through rock geochemical profile measurements supports the reliability of the target delineation, providing technical support for subsequent exploration engineering deployment.